Drug Combinations: Tests and Analysis with Isoboles
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چکیده
منابع مشابه
The Actions of Drug Combinations on the GABAA Receptor Manifest as Curvilinear Isoboles of Additivity.
Drug interactions are often analyzed in terms of isobolograms. In the isobologram, the line connecting the axial points corresponding to the concentrations of two different drugs that produce an effect of the same magnitude is termed an isobole of additivity. Although the isobole of additivity can be a straight line in some special cases, previous work has proposed that it is curvilinear when t...
متن کاملComments on "Isobolographic analysis for combinations of a full and partial agonist: curved isoboles".
Combinations of drugs are frequently used therapeutically to achieve an enhanced effect without using an excess quantity of either agent. If the drugs exert overtly similar action, e.g., two analgesics, the effect of the combination may be tested for additivity, i.e., an effect level that is achieved based on the individual drug potencies. But combinations of agonists will sometimes display eit...
متن کاملIsobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles
244 words Introduction 1007 words Discussion 990 words Appendix 466 words This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on June 2, 2004 as DOI: 10.1124/jpet.104.067264 at A PE T Jornals on July 9, 2017 jpet.asjournals.org D ow nladed from
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ژورنال
عنوان ژورنال: Current Protocols in Pharmacology
سال: 2016
ISSN: 1934-8282,1934-8290
DOI: 10.1002/0471141755.ph0919s72